Fold · Path, not pose

Show me the path.

Two-dimensional HP lattice. A hot walker versus a seven-stage cool. Energy is minus one per non-bonded hydrophobic contact. This is a toy. It does not fold real proteins.

Hot

T = 4.2

E 0 · 0 HH

Cool

Stage 1 / 7 · T = 3.2

E 0 · 0 HH

Square lattice, self-avoiding HP chain, Metropolis. Energy is −1 per non-bonded H–H neighbor. Seven cooling stages against a hot control. Not AlphaFold. Not PDB.

Energy vs moves

Hot E

0

Cool E

0

Hot contacts

0

Cool contacts

0

Sequence

HPHPPHHPHPPHPHHP

Dill 2D benchmark. Lattice toy, not a protein.

  1. Stage 1T = 3.2
  2. Stage 2T = 1.8
  3. Stage 3T = 1.1
  4. Stage 4T = 0.7
  5. Stage 5T = 0.42
  6. Stage 6T = 0.22
  7. Stage 7T = 0.08